GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs13014235 | 1 | rs10178982 | chr2:202227640 | ALS2CR12 | chr2:202153148-202222101:- | -0.2 | -5.3 | 1.39E-7 | Basal cell carcinoma |
| BRCA | cis | rs13014235 | 1 | rs10178982 | chr2:202227640 | PPIL3 | chr2:201735680-201753999:- | -0.15 | -4.08 | 4.87E-5 | Basal cell carcinoma |
| BRCA | cis | rs1577917 | 1 | rs1018184 | chr6:86648475 | SNHG5 | chr6:86386726-86388451:- | 0.55 | 17.78 | 3.7E-62 | Response to antipsychotic treatment |
| BRCA | cis | rs10183486 | 1 | rs10183486 | chr2:171990971 | MAP1D | chr2:172864804-172945586:+ | -0.15 | -3.87 | 0.000114 | Menopause (age at onset) |
| BRCA | cis | rs10183486 | 1 | rs10183486 | chr2:171990971 | TLK1 | chr2:171847333-172087824:- | -0.15 | -4.73 | 2.53E-6 | Menopause (age at onset) |
| BRCA | cis | rs9309473 | 1 | rs10187192 | chr2:73713500 | ALMS1P | chr2:73872046-73912692:+ | 0.22 | 5.37 | 9.75E-8 | Metabolite levels |
| BRCA | cis | rs2834188 | 1 | rs1018741 | chr21:34686345 | IFNAR1 | chr21:34696734-34732126:+ | 0.13 | 3.4 | 0.000692 | Narcolepsy |
| BRCA | cis | rs2834188 | 1 | rs1018742 | chr21:34686381 | IFNAR1 | chr21:34696734-34732126:+ | 0.13 | 3.4 | 0.000692 | Narcolepsy |
| BRCA | cis | rs6738627 | 1 | rs10187501 | chr2:165532454 | SLC38A11 | chr2:165754812-165812035:- | 0.17 | 5.02 | 6.14E-7 | circulating leptin levels;circulating leptin levels adjusted for BMI;Body fat percentage |
| BRCA | cis | rs13424612 | 1 | rs10189996 | chr2:240908800 | NDUFA10 | chr2:240900158-240964798:- | 0.27 | 6.86 | 1.13E-11 | Odorant perception (isobutyraldehyde) |
| BRCA | cis | rs9309473 | 1 | rs10190219 | chr2:73658331 | ALMS1P | chr2:73872046-73912692:+ | 0.28 | 7.04 | 3.32E-12 | Metabolite levels |
| BRCA | cis | rs712022 | 1 | rs1019217 | chr11:22842622 | GAS2 | chr11:22688160-22834546:+ | 0.11 | 3.4 | 0.000708 | Dialysis-related mortality |
| BRCA | cis | rs712022 | 1 | rs1019217 | chr11:22842622 | SVIP | chr11:22843600-22851382:- | 0.24 | 6.72 | 3.04E-11 | Dialysis-related mortality |
| BRCA | cis | rs60843830 | 1 | rs10193373 | chr2:281886 | SH3YL1 | chr2:218138-264810:- | -0.69 | -20.4 | 2.44E-78 | Spherical equivalent (joint main effects and education interaction) |
| BRCA | cis | rs2382817 | 1 | rs10193383 | chr2:219157692 | GPBAR1 | chr2:219125738-219128582:+ | -0.11 | -3.72 | 0.000208 | Crohn's disease;Ulcerative colitis;Inflammatory bowel disease |